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Higher doses may saturate the receptor and trigger compensatory downregulation faster than lower doses

The mechanistic case is strong

Vitamin B12 deficiency can occur due to dietary restrictions (vegetarian or vegan diets), absorption issues (pernicious anemia or gut disorders like celiac disease or Crohns disease), age-related changes in elderly patients, or long-term use of certain medicines

Optimizing foundational factors reduces side effect risk

Without a caloric deficit to force the body to oxidize those fatty acids as fuel, they circulate briefly and are re-stored

This represents a "bottom-up" approach to metabolic efficiency: by removing the enzymatic brakes, the cell's natural capacity for thermogenesis is restored