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ATM-deficient mice, worms, and cell models demonstrated accumulation of cytoplasmic DNA, hyperactivation of PARP1, and low NAD + levels 111,288

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(17) PLEASE NOTE: While these are interesting connections, we are not going as far as to recommend glutathione as a treatment for these diseases

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Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells

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Even though the pathophysiology of these conditions is well understood, it has not been adequately translated into effective treatments to stop or reverse the course of the disease ( One of the key challenges in developing effective therapies against NDs is the blood-brain barrier (BBB) which is very selective hence, hinders the delivery of therapeutic agents to the brain ( Recent breakthroughs in nanotechnology have provided novel approaches for overcoming the BBB

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