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ATM-deficient mice, worms, and cell models demonstrated accumulation of cytoplasmic DNA, hyperactivation of PARP1, and low NAD + levels 111,288

2021;2:e3719

(17) PLEASE NOTE: While these are interesting connections, we are not going as far as to recommend glutathione as a treatment for these diseases

Kinesin-1 regulates antigen cross-presentation through the scission of tubulations from early endosomes in dendritic cells

Even though the pathophysiology of these conditions is well understood, it has not been adequately translated into effective treatments to stop or reverse the course of the disease ( One of the key challenges in developing effective therapies against NDs is the blood-brain barrier (BBB) which is very selective hence, hinders the delivery of therapeutic agents to the brain ( Recent breakthroughs in nanotechnology have provided novel approaches for overcoming the BBB
