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Therefore, improving the glucose metabolic pathway and stabilizing the carnitine palmitoyltransferase-1 and -2 (cPT1/cPT2) mediated -oxidation of high-energy generating pathway are necessary for neuronal protection in alcoholics

Unlike hepatic insulin resistance, which primarily alters glucose production, peripheral resistance limits systemic glucose disposal, contributing to hyperglycemia, particularly in type 2 diabetes[32,34,36]