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Therefore, this study aims to review the doseresponse of Hg at the tissue and organ level and the underlying mechanisms that can potentially contribute to hypertension onset reported in animal studies, update the latest epidemiological evidence between Hg exposure and hypertension, and critically evaluate the weight of evidence on Hg exposure as a risk factor for hypertension

Couto N, Malys N, Gaskell SJ, Barber J (June 2013)

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Moreover, additional clinical trials are essential to validate the efficacy and safety of ferroptosis-targeting interventions

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Renin and ACE activities are required for physiological angiotensin II activation
