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Cofactor-dependent conformational heterogeneity of gad65 and its role in autoimmunity and neurotransmitter homeostasis

Traditional Chinese medicine formulation PAPZ of four ingredients (i.e., Radix Ginseng, Radix Angelicae Sinensis, Radix Polygalae, and Semen Ziziphi Spinosae) increased the protein expression of BDNF and alleviated the depressive behavior in corticosterone-challenged mice (90)

AOD-9604 offers a gentler approach with more selective fat targeting and fewer systemic effects, making it suitable for individuals who cannot tolerate GLP-1 agonists or prefer a more focused mechanism

doi: 10.1038/s41392-022-01080-1 2 XiangYZhangMJiangDSuQShiJ

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Finally, naturally occurring Treg can potently induce immunotolerance to self and foreign antigens, as the physiological function of Treg is thought to be the avoidance of autoimmunity by ensuring tolerance to self-antigens