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NLRP3 inflammasome can also be regulated by gut microbiota, which warrants further investigation [176]

While disentangling cause from effect is challenging, growing evidence suggests that modifying the gut microbiome through targeted dietary interventions like adding prebiotics, probiotics, or increasing fiber intake may slow disease progression or improve cognitive symptoms

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Some studies also discuss MAPK pathway effects, which are another part of the cellular response to stress and inflammation

Research suggests combining both mechanisms produces additive or synergistic satiety effects beyond either pathway alone