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Such local reactions are considered an expected part of therapy, but if a patient finds them unbearable or very painful, they should consult their dermatologist for possible adjustments
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In summary, based on the available data, UPA appears to be an effective drug with a favorable safety profile

Clinician awareness and implementation of vitamin B12 monitoring in metformin-treated patients

Dale RC, Candler PM, Church AJ, Wait R, Pocock JM, Giovannoni G
