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Potential Side Effects While generally well tolerated, Tesofensine can cause: Dry mouth Insomnia (avoid late-day dosing) Increased heart rate or blood pressure Mild headache or restlessness These are typically dose-dependent and often resolve with continued use or dose adjustment

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Compared with control, the nitric oxide donor SNP resulted in the dilation of 3-D cell disc significantly

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Our overall goal is to understand Parkinsons disease better, efficiently program and adjust DBS systems based on each patients neurophysiological signals, and ultimately minimize the variability of outcomes and DBS costs, so this therapy is effective and accessible for more patients, says the projects principal investigator, David Escobar, PhD, Director of Cleveland Clinics Neural Dynamics and Modulation Laboratory