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and RNA silencing by sequence specific methylation of DNA, resulting in suppression of transcription, known as transcriptional gene silencing (TGS)

Furthermore, their research demonstrated a substantial enhancement in the level of mitochondrial superoxide in human OA cartilage in vivo , which was associated with the expression of catabolic genes in OA cartilage

These behavioral disturbances amplify microglial activation and the production of proinflammatory cytokines, increasing susceptibility to depression and anxiety disorders [91,92,93,94]

doi: 10.3389/fimmu.2021.656364 123 Mndez-FerrerSBonnetDSteensmaDPHasserjianRPGhobrialIMGribbenJGet al

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