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Given the great degree of distress experienced by those with acne, any intervention that has the potential to diminish the most evident acne lesions, the inflammatory lesions, and improve mental outlook, is certainly worth investigating

Zhang D, Li M (2019) Puerarin prevents cataract development and progression in diabetic rats through Nrf2/HO-1 signaling

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Similar situation is for the psychological impact to the development of insulin resistance

While the treatment didnt change the levels of a key reproductive hormone in the brain, it did increase the levels of another hormone that stimulates testosterone production