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Likewise, no effect was observed on downstream components of the Insulin/IGF-1 signaling pathway with mAb treatment in females (Supplementary Fig 3), but L2-Cmu attenuated S6 activation in male hypothalamus (Supplementary Fig 4c

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The objective response rate (ORR) by imaging was 72.1% (95% CI, 56.3-84.7%) in the camrelizumab plus chemotherapy group and 53.3% (95% CI, 37.9-68.3%) in the chemotherapy-only group

Prior to the procedure of triplicate injection on the HPLC device, the samples were filtered through a 0.45 m Millipore membrane filter

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