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This protective effect is likely due to the ability of Alda-1 to decrease interaction of 4-HNE with key residues such as Cys302, Cys301 and Cys303, thereby preventing formation of aldehyde adducts (26)

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doi: 10.1002/1098-2752(2000)20:7 3.0.CO;2-C 38 KerriganCLDanielRK

When ligands attach to death receptors, the extrinsic route is started, affecting the activation of caspases (Kumar et al

All GSH experiments were performed using drug plates with 1 mM concentration throughout the entirety of the experiment refreshed every 2 days