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Okuyama K

Skinner AM, Price DA, Addison GM, Clayton PE, Mackay RI, Soo A, Mui CY

Adverse events reported with HQ use include contact dermatitis, nail discoloration, permanent leukoderma, and hypopigmentation of the surrounding normal skin that has been treated with HQ (halo effect)

Beyond this threshold, there is a risk of impairing copper homeostasis [54,55,56]

The accepted treatment is daily intramuscular injections of vitamin B12 and supplemental oral betaine.9,13 MAT The MAT enzyme controls the transfer of an adenosyl group from ATP to methionine to form SAM, the first step in the methionine cycle