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Influence of the route of administration on the protective effect of L-carnitine on acute hyperammonemia

[DOI] [PubMed] [Google Scholar] 5.Rostom A, Murray JA, Kagnoff MF

Springer, pp 283295 Boudrault C, Bazinet RP, Ma DW (2009) Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimers disease

The following genes were assessed with a SYBR green fluorophore: interleukin (IL)-1, organic cation/carnitine transporter (OCTN) 2, Cpt1a, Cpt2, medium-chain acyl-CoA dehydrogenase (MCAD), superoxide dismutase (Sod)2, catalase (CAT), glutathione peroxidase (Gpx)1, Gpx4, divalent metal transporter 1 (DMT-1), and Hamp (hepcidin coding gene)

In contrast, significantly increased HO-1 expression was reported in plasma and brain from AD subjects compared with age-matched control subjects (385, 386)

Pralidoxime contains a quaternary ammonium group, and is not known to cross the blood brain barrier (Gupta & Parmar, 2023)