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Moreover, reduction in the action of sirtuin coupled with hyperacetylation of histone sites including H3K27, H3K9, and H2BK15 at the PD prefrontal cortex, have been profoundly dysregulated at genomic levels hence associated with the pathology of PD (Park et al., 2016)

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Patients describe the effect as a cleaner, more sustained mental clarity: better ability to focus without feeling overstimulated

doi: 10.3390/ijms21186969