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Clean the injection site with an alcohol swab, pinch the skin to create a fold, insert the needle at a 45-90 degree angle, slowly inject the solution, then withdraw the needle and apply gentle pressure to the site

Let the vial rest between additions if needed

1 Effect of semaglutide treatment or placebo on waist circumference from baseline to week 104 by subgroups

Whichever route a protocol specifies, the reconstitution math below is what governs the injectable draw

Over a comparable 68-week period, trial participants saw roughly a 16% reduction in body weight a substantially larger effect than liraglutide

This can happen with improper storage, particularly if the medication was left out of the fridge for too long or exposed to extreme temperatures