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FMT induces cognitive improvement while lessening the accumulation of A in the brain, as shown in animal models of AD, as shown in Table 3

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For all RT-qPCR assays, target gene expression levels were normalized by 18S ribosomal RNA (18S ribosomal N1) (NR_145820.1) levels

Under mitochondrial stress, mitochondrial DNA can be activated via specific mechanisms and released into the cytoplasm or extracellular space, where it can be recognized by receptors such as cGAS, TLR9, and NLRP3

TABLE 4 Leaves-derived secondary metabolites reported in selected underutilized berry species

Succinyl-CoA, along with glycine, contributes all the carbon and nitrogen atoms required for the synthesis of heme and for non-hepatic tissue utilization of ketone bodies