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Applied Veterinary Clinical Nutrition (2013)

It is proposed that low and moderate doses of tea polyphenols produce lower levels of ROS, which activates Nrf2 to attenuate oxidative stress, whilst high dose of tea polyphenols produce high levels of ROS and induce toxicity [185]

Yet, large goiters can obstruct the trachea and esophagus and damage the recurrent laryngeal nerves

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The activation of TFEB requires modification of a specific lysine residue in the translation initiation factor 5A (eIF-5A) generating what is called hypusine (derived from hy droxy pu trescine and ly sine ) which involves spermidine as outlined in the Polyamines in Protein Modification below

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