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Description
It allows researchers to study how parts of human growth hormone can affect fat and energy metabolism, without the full hormones effects
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JBSNF-000088, a small-molecule analog of NA, is able to be bound to NNMT and to be methylated in the NNMT structure, with SAM being correspondingly demethylated to SAH [58]
In vitro studies examining receptor-independent growth hormone signalling
The interest traces to a 2014 Nature paper showing that knocking down NNMT in fat and liver protected mice against diet-induced obesity, glucose intolerance, and fatty liver, partly by shifting adipose NAD+ and SAM levels [4]
