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Upon activation, microglia produce pro-inflammatory cytokines which can increase permeability of the BBB, allowing passage of immune cells into the brain parenchyma [15]

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Early in the disease course, ferroptotic processes may be subtle and localized, potentially yielding false-negative results

Glycolysis inhibition in CRC is limited by systemic toxicity and resistance via TRX1 upregulation, which enhances SLC1A5 expression, glutamine transport, and GSH synthesis to counteract cytotoxicity

The observation of metal sulphides as neutral fragments in the unimolecular decomposition of bio-organic ions is relatively rare, and only one case has been very recently reported in a study of lead-binding metallothionein [122] (see below)