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While this provides a baseline comparison, it does not account for factors such as differences in cellular uptake, biodistribution, or inherent cytotoxicity unrelated to activation mechanisms

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In healthy individuals, the potential catalytic activity of these metals is negatively regulated through binding to proteins such as ferritin and transferrin [69]

2), which can be specific and mediated by binding to a particular receptor or non-specific, such as cationization and adsorptive-mediated transcytosis (Fig

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