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Binding of -MSH/ACTH to MC1R activates adenylate cyclase (AC), which catalyses the production of the secondary messenger cAMP [32]

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Despite the primary injury due to mechanical force, diffuse and multifocal damage often appears, leading to diffuse axonal injury by blunt force of shearing, tearing, and stretching of the axon and further damage of the long-distance white matter connection, with large-scale network disconnection as the core mechanism of cognitive impairment

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Loren Pickart, who noticed that plasma from young adults restored normal protein synthesis patterns in aged liver cells

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