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In 2008, Marcus Conrad and his colleagues reported that genetic inactivation of GPX4 induced a non-apoptotic cell death driven by lipid peroxidation that could be suppressed by alpha-tocopherol (Seiler et al., 2008), and that overexpression of xCT protected cells from lipid-peroxidation-induced non-apoptotic cell death (Banjac et al., 2008)

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J Mol Model 11:194199

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[DOI] [PubMed] [Google Scholar] Meister A, Tate SS

however, their effects on the reproductive system of patients are often overlooked, especially their impact on germ cell cytogenesis, embryonic development, and reproductive system maturation