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Description
Most estrogens are hydroxylated to form 2- and 4-catechol estrogens in cells, which are further oxidized to form semiquinones and quinones such as catecholestrogen-3,4-quinones, which are also the most carcinogenic form [264]
Thus a significant portion of an orally administered drug can be metabolized before it reaches the central circulation

10.1002/jor.22193 65 ZhaoS.NishimuraT.ChenY.AzelogluE

[DOI] [PMC free article] [PubMed] [Google Scholar] 224.Guo Q., Jin Y., Chen X., Ye X., Shen X., Lin M., Zeng C., Zhou T., Zhang J

ASCO Annual Meeting Proceedings Part I Clinical Oncol:25:18S, 2007

In vitro evaluation of aptamer-based reversible inhibition of anticoagulant activated protein C as a novel supportive hemostatic approach
