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These sirtuins help preserve collagen by stopping MMP-1 gene transcription that breaks down collagen

(en) Berlin H, Berlin R, Brante G, Oral treatment of pernicious anemia with high doses of vitamin B12 without intrinsic factor Acta Med Scand

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The enzymes encoded by these two genes function at the initial steps of corrin ring synthesis controlling the metabolic flow entering the vitamin B12 biosynthesis pathway (27)

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