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Matt Kaeberlein (UW Medicine, Optispan) observed: Expecting a single drug to meaningfully alter the course of Alzheimers once cognitive decline is underway is an extraordinarily high bar. The EVOKE population already had MCI or mild dementiameaning pathological cascades were well-established

The technique has recently been incorporated on a balloon that can be inserted through the biopsy channel of a standard endoscope

For example: Alcohol or sedatives may worsen confusion, depression, or emotional flatness

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