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10.1371/journal.pgen.1004228 218
J Immunol 2005, 175: 43204330
By anchoring to these positively charged side chains, CLR01 disrupts the electrostatic and hydrophobic contacts necessary for oligomer and fibril formation
Most patients require multiple sessions, typically four to six treatments, spaced four to six weeks apart
CIPN affects sensory, motor and autonomic nerves and is one of the most common adverse events caused by chemotherapeutic agents, which in severe cases leads to dose reduction or treatment cessation, with increased mortality
