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But rapamycin has uncertain efficacy and potential adverse effects (Moghadamnia et al., 2024)

The causal role cfDNA in the inflammatory response to trauma was shown by the group of Carl Hauser at Harvard (67, 69)

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While newer MS therapies may offer higher efficacy in aggressive disease, the favorable safety profile and convenience of Plegridy make it a key systemic strategy for long-term modulation of neuroinflammation in MS