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(1996) Astrocytes protect neurons from hydrogen peroxide toxicity

The rats received pentadecapeptide BPC 157 (0.16 g/ml) or nothing in the drinking water (12.0 ml/rat) until the sacrifice or once daily, intraperitoneally BPC 157 10.0 g/kg, 10.0 ng/kg, or saline (5.0 ml/kg b.w.)

Thus, while dietary antioxidants may offer supportive benefits, they should not be considered reliable surrogates for therapeutic efficacy without robust clinical trial evidence

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In addition, our study supports the rationale for the development of LDHB-specific inhibitors for the clinical implementation of our findings and provides further evidence that targeting oncogene-specific ferroptosis mechanisms may facilitate the identification of rational strategies for the treatment of KRAS-driven lung cancer