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For example, it was discovered that feeding mice induced by dextran sulfate sodium (DSS) with Lactobacillus helveticus-fermented milk rich in L-citrulline could decrease the expression of pro-inflammatory factors such as IL-6, TNF-, and IFN-, and enhance the expression of tight junction proteins (ZO-1, occludin, and claudin-1), thereby alleviating colonic injury [74] (Figure 3)

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One of them is the small number of patients, which may lead to false positives, especially as we made no correction for multiple comparisons, given the exploratory nature of this study

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