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Citrulline is converted to arginine through sequential catalysis by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase, and subsequently metabolized by arginase 1 to produce urea and ornithine

Cysteinyl leukotrienes Leukotrienes C 4 , D 4 and E 4 are potent lipid mediators generated by oxidation of arachidonic acid released from membrane phospholipids and conjugated to glutathione, involving enzymes such as phospholipases, ALOX5 and LTC4S

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5.3 Mechanisms of CS pathway activation during preeclampsia We have discussed earlier that altered CS signaling pathways are critical players in the onset and severity of preeclampsia