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These include some heartburn medicines, including esomeprazole (Nexium), famotidine (Pepcid AC), lansoprazole (Prevacid), omeprazole (Prilosec OTC), pantoprazole (Protonix), rabeprazole (Aciphex), as well as some diabetes, gout, and chemotherapy drugs

3.5 Chemotherapy-induced renal injury 3.5.1 Cisplatin-induced nephrotoxicity Cisplatin (CP) is a prominent chemotherapeutic agent utilized in the treatment of solid tumors (Fuertes et al., 2003)

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Furthermore, GPX4-knockout Treg cells show increased production of mitochondrial superoxide and IL-1, which, in turn, amplify Th17 cellular responses