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Melanotan-II has a cyclic structure and broader melanocortin receptor activity compared to the more selective Melanotan-I peptide

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Subsequently, these oxidized lipids activate LOX-1 and TLRs on the surface of endothelial cells, triggering a series of endothelial dysfunction such as eNOS decoupling, apoptosis and iron death

Supplementation of folic acid and vitamin B12 is routinely provided 1 week prior to chemotherapy aiming to minimise its cytotoxic effects, whereas the administration of oral or intravenous dexamethasone does not seem to reduce pemetrexed-associated cutaneous ADRs [4, 5]