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Numerous signals, including neurotransmitters, hormones, ions, peptides, and even photons in the retina, can activate the hundreds of GPCRs that are present in the genome

This demonstrates the need to consider the use of a prodrug prior to clinical evaluation, especially in the case of the traditionally problematic phosphonic acid, in order to overcome the double negative charge at physiological pH

Both testosterone aromatization and HCG-induced intratesticular estrogen production contribute to total estrogen load

Under the optimal cut-off value, the models sensitivity was 92.6% (50/54) and the specificity was 93.7% (44/47), and the average accuracy based on 100 cross validations was 88.9% ( Figure 4 )