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Statistical analysis In the in vitro alkaline comet assay, significant differences between control and treated cells were evaluated using the unpaired Welchs t -test, one-tailed (PCLiS, PHH and HepG2 cells), as equal variance was not assumed, or paired t -test, one-tailed (PRH, due to variability of each rat), using TIBCOs Statistica (StatSoft GmbH, Germany)

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