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We also provide deep insights into the functions of TGF- signaling in physiological conditions as well as in pathological processes
However, interpretation of these signatures may be confounded by kidney function and medication use, and clinical translation will require rigorous external validation, particularly in prospective cohorts and trials specifically designed for DKD
In mice, researchers observed that MOTS-c in muscle and blood drops as the animals age, coinciding with the onset of age-related insulin resistance
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