glutathione parkinsons study Our Science – Nacuity Pharmaceuticals Frontiers | Metabolic Parkinson's disease

[DOI] [PubMed] [Google Scholar] 72.Haddad S., Wang Y., Galy B., Korf-Klingebiel M., Hirsch V., Baru A.M., Rostami F., Reboll M.R., Heineke J., Flgel U., et al

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Cell Res 360 , 105112 (2017)

Dichloroacetate (DCA, Ceresine) is an inhibitor of mitochondrial pyruvate dehydrogenase kinase, which inhibits pyruvate dehydrogenase, a gatekeeping enzyme for the entry of pyruvate into the tricarboxylic acid cycle

Taken together, our results suggest that the Chac1 protein expression is regulated in translational and post-translational fashion due to the Kozak-like sequence in the 5UTR and the ubiquitin-mediated pathways

Consequently, it has been suggested that a chronical combined administration of MEM and NSAIDs could be a suitable strategy to delay the onset or slow the progression of AD [83]