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3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure ( G93A gene, leading to significantly increased levels of MDA, GSH, and ROS, along with reduced expression of SLC7A11 and GPX4

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An example of neural stimuli is the activation of the fight-or-flight response by the sympathetic nervous system
Vasculogenic erectile dysfunction and metabolic syndrome

Clinical trials have shown positive results regarding the efficacy of AOD-9604 for weight loss in humans, with one study reporting an average loss of 2.6 kg over 12 weeks, compared to 0.8 kg in the placebo group