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These results indicated that a large number of effector cells accumulated in lung tissue after CD5/ LNP-FAPCAR 2.2 treatment because of T cell immune activation, which partially resulted from transient FAPCAR-T recruited in the fibrotic lung

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Notably, all patients had previously been treated with pentosan polysulfate, which is currently the only FDA approved treatment for interstitial cystitis, and had not responded

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