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IC/BPS affects an estimated 4-12 million patients in the United States [1]

The autophagy-inhibitor bafilomycin A1 (100 nM) and the autophagy-inducer rapamycin (10 M) were used as negative and positive controls, respectively

6 ClinicalTrials.gov REDEFINE 1 (NCT05567796)Registry record for the pivotal phase 3 CagriSema weight-management trial in adults without type 2 diabetes

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By the negative crosstalk between WNT and PPAR, lithium administration, by inhibiting the GSK-3 could act as a PPAR antagonist and lead to an increase in the WNT pathway, resulting in diminution of oxidative stress

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