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J Asian Nat Prod Res

S2CID 46535145

These miRNAs reside in intronic regions within SREBP-1 and 2, the key transcriptional regulators of lipid metabolism 87 , and control the expression of carnitine O -octanoyltransferase (CROT), CPT1A, hydroxyacyl coenzyme A (hydroxyacyl-CoA) dehydrogenase subunit beta (HADHB), and AMPK, targeting their 3 UTR 88

While Professor Funder said the study found an important link between L-carnitine and the build-up of plaque in blood vessels, it was one of several factors likely to be causing heart disease, including cholesterol, saturated fat, genetic factors and certain infections

Their presence signals more resilient bacteria to grow, while less resilient but beneficial bacteria may not survive (Caparrs-Martn et al., 2017)

Therefore, optimizing this pathway through sufficient L-Carnitine levels can improve overall energy efficiency, particularly during prolonged physical activity or states of high energy demand