melanotan 2 studies 2016 II (MT2) Peptide | Melanocortin Agonist Melanocortin agonism in a social

Description

10 million people in the US are affected 90 percent diagnosed in winter 10 percent diagnosed in summer Incidence increases as you go further north in latitude Symptoms are present for about 40 percent of the year Does not necessarily occur every year, about 50 percent skip years Symptoms of major depression may include: (SAD) Feeling depressed most of the day, nearly every day Losing interest in activities you once enjoyed Experiencing changes in appetite or weight Having problems with sleep Feeling sluggish or agitated Having low energy Feeling hopeless or worthless Having difficulty concentrating Having frequent thoughts of death or suicide NOTE THERE IS A NATIONAL SUICIDE CRISIS HOTLINE 24/7- JUST DIAL 988 For winter-pattern SAD, additional specific symptoms may include: Oversleeping (hypersomnia) Overeating, particularly with a craving for carbohydrates Weight gain Social withdrawal (feeling like hibernating) Specific symptoms for summer-pattern SAD may include: Trouble sleeping (insomnia) Poor appetite, leading to weight loss Restlessness and agitation Anxiety Episodes of violent behavior Winter blues statistics Up to 14 percent of the general population experience some form of winter blues As latitudes go up incidence also goes up- Winter blues symptoms (not a clinical diagnosis) Lack the motivation to complete some tasks but be able to handle major tasks Still able to go to work and take care of home Have trouble sleeping Spend more time in bed than usual Limited to winter months Managed with lifestyle changes Risk factors for both winter blues and SAD Age-Younger people are more susceptible to winter blues than older population Sex-Females are four times more likely be affected Geography- Higher latitudes increase incidence Family or personal history of depression The role of melatonin cortisol in both SAD and winter blues Melatonin- the sleep hormone As stated in part 1, melatonin is produced in 2 places in the body- the pineal gland and mitochondria of cells

Drake C, Roehrs T, Shambroom J, Roth T

Brain and liver are essentially negative for P-cadherin

It is an extraordinary painting from the end of Titians career

Families that harbor mutations of the tumor suppressor gene TP53 (i.e., those with Li-Fraumeni syndrome) are prone to the development of many types of cancer