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For both assays, transcriptional activity was quantified by measuring secreted Gaussia luciferase signals in the culture supernatant using the Secrete-Pair Dual Luminescence Assay Kit (GeneCopoeia) according to the manufacturers instructions

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A significantly higher [ 11 C] acetate uptake was observed in several brain regions, including the entorhinal cortex, hippocampus and temporal cortex in patients with AD compared with controls 373

Choice E: A probability of 3 of 4 represents the overall chance that two carrier parents will have a phenotypically normal child in an autosomal recessive inheritance pattern