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For example, one study found that after taking 1,000 mcg of oral vitamin B12, only about 1.3% (13 mcg) is absorbed into the bloodstream

Others experience fatigue, especially early in treatment when their caloric intake drops significantly

Often, people will notice the effects of B12 injections within 24 to 72 hours after their first dose

However, experts agree that it is necessary for vegans to take a B12 supplement to ensure that enough of it is absorbed

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