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Nuclear ruptures are associated with multiple human laminopathies, and can occur in normal cells that experience mechanical stress, as from migration in confined environments [89,90]

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Prior to the availability of enzyme-replacement therapy, individuals with LAL-D were treated with lipid lowering medication, liver transplant, and stem cell transplant, none of which corrected the multisystem nature of the disorder

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Am J Surg Pathol 1994

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