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These impairments typically include sensory axonal peripheral neuropathy (stocking and glove neuropathy), which is accompanied by numbness, paresthesias, ongoing/spontaneous pain hypersensitivity to mechanical and thermal stimuli in the hands and feet [17], and motor symptoms such as distal weakness, reduced or absent Achilles tendon reflexes, paresthesias, breath dysregulation, abnormal swallowing, laryngospasm, muscle cramps, jaw stiffness, visual field changes, muscle weakness, reduced balance control and insecure gait, the mechanisms of which are not fully understood [20, 33, 40, 41]

doi:10.1586/14737175.2013.814930

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