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BHB mediates the protective effect of dapagliflozin on mitochondrial function in vitro BHB is the most abundant ketone body, and we found significantly higher levels of free fatty acids and BHB in the serum and renal tissues of dapagliflozin-treated mice with DKD (Figure 5AC)

[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Campbell AK, Matthews SB, Vassel N, et al

Thus a drug like cocaine that blocks DA transport back into the terminal, promoting its accumulation in the extracellular space, while also increasing the frequency of DA release events in the NAc (9), triggers high DA levels that can activate both D1R and D2R

There is a clear and known explanation mechanism for this

The results obtained have revealed that, in vitro, both compds

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