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Association between HCV and Mixed Cryoglobulinemia Multiple reports have shown a close association between HCV and mixed cryoglobulinemia, most often type II cryoglobulinemia70 to 90% of persons with mixed cryoglobulinemia have evidence of chronic HCV.[17,23] With HCV-related mixed cryoglobulinemia, immune complexes comprised of immunoglobulin and HCV particles precipitate in many organs, including the skin, kidneys, and peripheral nerve fibers.[16,18] Investigators have postulated that expansion of rheumatoid factor activity and cryoprecipitability is responsible for the vasculitis

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