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Subsequent studies showed that several GlyT1 inhibitors were effective in preclinical models predictive of antipsychotic and procognitive effects, including models relevant to Alzheimers disease and cerebral ischemia

Radiotherapy can adversely affect the function of normal tissues and organs within the target area, compromising the health and function of the gastrointestinal mucosa and potentially causing inflammation or ulcers (12, 13)