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Hair pigmentation is regulated by melanogenesis within the follicle and modulated by various factors, including melanocyte-stimulating hormone (MSH), adrenocorticotropic hormone (ACTH), endothelin-1, prostaglandins, leukotrienes, fibroblast growth factors, nitric oxide, catecholamines, as well as essential vitamins and minerals

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This process, called collagen maturation, can last several months and is responsible for long-term improvements in skin texture, firmness, and the reduction of fine lines or scars

doi: 10.1002/jsfa.7117, 20